PoE Poisonberry Tincture Mods – Path of Exile

PoE Poisonberry Tincture

Inflicts Mana Burn every 0.43 Seconds
6 Second Cooldown when Deactivated

Requires Level 45

  • 20% chance to Poison with Melee Weapons
  • (60–90)% increased Damage with Poison from Melee Weapons

How to use it?

Right click to activate. Only one Tincture in your belt can be active at a time. Mana Burn causes you to lose 1% of your maximum Mana per stack per second. Can be deactivated manually, or will automatically deactivate when you reach 0 Mana.

Potent Poisonberry Tincture of Ire

List of PoE Poisonberry Tincture Mods

Name Level Stats Tags Category
Snapping 1 Damage Penetrates (4-5)% Lightning Resistance
  • elemental_damage
  • damage
  • elemental
  • lightning
  • attack
 Prefix
Crackling 1 Damage Penetrates (6-8)% Lightning Resistance
  • elemental_damage
  • damage
  • elemental
  • lightning
  • attack
 Prefix
Sparking 60 Damage Penetrates (9-12)% Lightning Resistance
  • elemental_damage
  • damage
  • elemental
  • lightning
  • attack
 Prefix
Ashfall 45 Cover Enemies in Ash on Hit for (4-5) seconds against Enemies that are on Full Life
  • elemental
  • fire
  • attack
 Prefix
Ember 45 Cover Enemies in Ash on Hit for (6-7) seconds against Enemies that are on Full Life
  • elemental
  • fire
  • attack
 Prefix
Cindered 72 Cover Enemies in Ash on Hit for (8-12) seconds against Enemies that are on Full Life
  • elemental
  • fire
  • attack
 Prefix
Wilting 45 Hits Inflict (2-3) Withered Debuffs for 2 seconds on Enemies that are on Full Life
  • chaos
  • attack
 Prefix
Drooping 45 Hits Inflict (4-5) Withered Debuffs for 2 seconds on Enemies that are on Full Life
  • chaos
  • attack
 Prefix
Withering 72 Hits Inflict (6-7) Withered Debuffs for 2 seconds on Enemies that are on Full Life
  • chaos
  • attack
 Prefix
Searing 1 Damage Penetrates (4-5)% Fire Resistance
  • elemental_damage
  • damage
  • elemental
  • fire
  • attack
 Prefix
Sizzling 1 Damage Penetrates (6-8)% Fire Resistance
  • elemental_damage
  • damage
  • elemental
  • fire
  • attack
 Prefix
Blistering 60 Damage Penetrates (9-12)% Fire Resistance
  • elemental_damage
  • damage
  • elemental
  • fire
  • attack
 Prefix
Grasping 70 (6-8)% chance to inflict a Grasping Vine on Hit
Prefix
Clutching 70 (9-11)% chance to inflict a Grasping Vine on Hit
Prefix
Ensnaring 81 (12-14)% chance to inflict a Grasping Vine on Hit
Prefix
Potent 1 35% increased effect
(47-51)% increased Mana Burn rate
Prefix
Concentrated 49 35% increased effect
(42-46)% increased Mana Burn rate
Prefix
Enriched 84 35% increased effect
(37-41)% increased Mana Burn rate
Prefix
Thin 1 (35-31)% reduced effect
50% reduced Mana Burn rate
Prefix
Diluted 49 (30-26)% reduced effect
50% reduced Mana Burn rate
Prefix
Measured 84 (25-21)% reduced effect
50% reduced Mana Burn rate
Prefix
Herbal 1 (11-13)% increased effect
Prefix
Natural 35 (14-16)% increased effect
Prefix
Medicinal 64 (17-19)% increased effect
Prefix
Horticultural 85 (20-22)% increased effect
Prefix
Frosted 1 Damage Penetrates (4-5)% Cold Resistance
  • elemental_damage
  • damage
  • elemental
  • cold
  • attack
 Prefix
Chilled 1 Damage Penetrates (6-8)% Cold Resistance
  • elemental_damage
  • damage
  • elemental
  • cold
  • attack
 Prefix
Icy 60 Damage Penetrates (9-12)% Cold Resistance
  • elemental_damage
  • damage
  • elemental
  • cold
  • attack
 Prefix
Rippling 70 Melee Strike Skills deal Splash Damage to surrounding targets, with (50-35)% reduced Area of Effect
Prefix
Echoing 70 Melee Strike Skills deal Splash Damage to surrounding targets, with (34-20)% reduced Area of Effect
Prefix
Resonating 81 Melee Strike Skills deal Splash Damage to surrounding targets, with (19-0)% reduced Area of Effect
Prefix
Frostfall 45 Cover Enemies in Frost on Hit for (4-5) seconds against Enemies that are on Full Life
  • elemental
  • cold
  • attack
 Prefix
Snowdrift 45 Cover Enemies in Frost on Hit for (6-7) seconds against Enemies that are on Full Life
  • elemental
  • cold
  • attack
 Prefix
Blizzard 72 Cover Enemies in Frost on Hit for (8-12) seconds against Enemies that are on Full Life
  • elemental
  • cold
  • attack
 Prefix
Angry 70 (5-10)% chance to gain 1 Rage when you Hit a Rare or Unique Enemy
Prefix
Outraged 70 (11-15)% chance to gain 1 Rage when you Hit a Rare or Unique Enemy
Prefix
Apoplectic 81 (16-20)% chance to gain 1 Rage when you Hit a Rare or Unique Enemy
Prefix
Hexing 45 (6-8)% chance to Curse Enemies with a random Hex on Hit
Prefix
Profane 45 (9-11)% chance to Curse Enemies with a random Hex on Hit
Prefix
Vile 72 (12-14)% chance to Curse Enemies with a random Hex on Hit
Prefix
Frigid 70 Chills from your Hits always reduce Action Speed by at least (10-12)%
Prefix
Subzero 81 Chills from your Hits always reduce Action Speed by at least (13-15)%
Prefix
Potent 45 Poisons you inflict on non-Poisoned Enemies deal (50-100)% increased Damage
Prefix
Virulent 45 Poisons you inflict on non-Poisoned Enemies deal (101-200)% increased Damage
Prefix
Pestilent 72 Poisons you inflict on non-Poisoned Enemies deal (201-300)% increased Damage
Prefix
Overwhelming 1 Overwhelm (9-12)% of Physical Damage Reduction
  • physical
  • attack
 Prefix
Battering 1 Overwhelm (13-16)% of Physical Damage Reduction
  • physical
  • attack
 Prefix
Pummeling 60 Overwhelm (17-25)% of Physical Damage Reduction
  • physical
  • attack
 Prefix
Charring 70 (14-18)% chance to refresh Ignite Duration on Hit
Prefix
Singeing 70 (9-13)% chance to refresh Ignite Duration on Hit
Prefix
Roasting 81 (19-25)% chance to refresh Ignite Duration on Hit
Prefix
Lucid 1 (13-17)% increased Cooldown Recovery Rate
Prefix
Perceptive 30 (18-22)% increased Cooldown Recovery Rate
Prefix
Insightful 58 (23-27)% increased Cooldown Recovery Rate
Prefix
Astute 82 (28-32)% increased Cooldown Recovery Rate
Prefix
Needling 70 (9-13)% chance to refresh Bleeding Duration on Hit
Prefix
Skewering 70 (14-18)% chance to refresh Bleeding Duration on Hit
Prefix
Lacerating 81 (19-25)% chance to refresh Bleeding Duration on Hit
Prefix
Sustained 1 (17-15)% reduced Mana Burn rate
Prefix
Tenacious 30 (20-18)% reduced Mana Burn rate
Prefix
Persistent 58 (23-21)% reduced Mana Burn rate
Prefix
Persevering 80 (26-24)% reduced Mana Burn rate
Prefix
Holy 45 (3-5)% chance to create Consecrated Ground when you Hit a Rare or Unique Enemy, lasting 8 seconds
Prefix
Pious 45 (6-8)% chance to create Consecrated Ground when you Hit a Rare or Unique Enemy, lasting 8 seconds
Prefix
Consecrated 72 (9-11)% chance to create Consecrated Ground when you Hit a Rare or Unique Enemy, lasting 8 seconds
Prefix
Subduing 1 (30-40)% increased Damage against Enemies that are on Low Life
  • damage
  • attack
 Prefix
Overpowering 1 (50-60)% increased Damage against Enemies that are on Low Life
  • damage
  • attack
 Prefix
Conquering 60 (75-90)% increased Damage against Enemies that are on Low Life
  • damage
  • attack
 Prefix
Infused 45 (10-12)% increased Damage for each Non-Instant Spell you've Cast in the past 8 seconds
Prefix
Ensorcelled 45 (13-15)% increased Damage for each Non-Instant Spell you've Cast in the past 8 seconds
Prefix
Overloaded 72 (16-18)% increased Damage for each Non-Instant Spell you've Cast in the past 8 seconds
Prefix
Profane 1 Damage Penetrates (4-5)% Chaos Resistance
  • chaos
  • attack
 Prefix
Tainted 1 Damage Penetrates (6-8)% Chaos Resistance
  • chaos
  • attack
 Prefix
Debased 60 Damage Penetrates (9-12)% Chaos Resistance
  • chaos
  • attack
 Prefix
Crushing 45 Crush Enemies for (4-5) seconds when you Hit them while they are on Full Life
  • physical
  • attack
 Prefix
Smashing 45 Crush Enemies for (6-7) seconds when you Hit them while they are on Full Life
  • physical
  • attack
 Prefix
Pulverising 72 Crush Enemies for (8-12) seconds when you Hit them while they are on Full Life
  • physical
  • attack
 Prefix
of Phasing 1 (10-20)% chance to gain Phasing for 4 seconds on Kill
Suffix
of Stealth 1 (21-30)% chance to gain Phasing for 4 seconds on Kill
Suffix
of Shadows 60 (31-40)% chance to gain Phasing for 4 seconds on Kill
Suffix
of Sabotage 1 Hits Steal Endurance Charges
  • endurance_charge
  • attack
 Suffix
of Enervation 1 Hits Steal Power Charges
  • power_charge
  • attack
 Suffix
of Poaching 1 Hits Steal Frenzy Charges
  • frenzy_charge
  • attack
 Suffix
of Plunder 1 (10-20)% increased Rarity of Items Dropped by Slain Enemies
Suffix
of Raiding 1 (21-30)% increased Rarity of Items Dropped by Slain Enemies
Suffix
of Archaeology 60 (31-40)% increased Rarity of Items Dropped by Slain Enemies
Suffix
of Victory 1 Recover (5-10)% of Life on Killing a Rare or Unique Enemy
Suffix
of Conquest 1 Recover (11-15)% of Life on Killing a Rare or Unique Enemy
Suffix
of Triumph 60 Recover (16-20)% of Life on Killing a Rare or Unique Enemy
Suffix
of Glancing 70 Projectiles have (11-15)% chance to be able to Chain when colliding with terrain
Suffix
of Rebounding 70 Projectiles have (16-20)% chance to be able to Chain when colliding with terrain
Suffix
of Ricochet 81 Projectiles have (21-30)% chance to be able to Chain when colliding with terrain
Suffix
of Ire 1 +(9-13)% to Melee Weapon Critical Strike Multiplier
  • damage
  • attack
  • critical
 Suffix
of Anger 32 +(14-18)% to Melee Weapon Critical Strike Multiplier
  • damage
  • attack
  • critical
 Suffix
of Rage 60 +(19-23)% to Melee Weapon Critical Strike Multiplier
  • damage
  • attack
  • critical
 Suffix
of Fury 73 +(24-28)% to Melee Weapon Critical Strike Multiplier
  • damage
  • attack
  • critical
 Suffix
of Ferocity 85 +(29-33)% to Melee Weapon Critical Strike Multiplier
  • damage
  • attack
  • critical
 Suffix
of Reach 1 +(0.1-0.2) metres to Melee Strike Range
Suffix
of Skies 1 +(0.3-0.4) metres to Melee Strike Range
Suffix
of Worlds 60 +(0.5-0.6) metres to Melee Strike Range
Suffix
of Rejuvenation 1 Gain (2-3) Life per Enemy Hit with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Restoration 50 Gain (3-4) Life per Enemy Hit with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Regrowth 77 Gain (5-7) Life per Enemy Hit with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Battering 40 Melee Weapon Hits have (30-39)% chance to ignore Enemy Physical Damage Reduction
  • physical_damage
  • damage
  • physical
  • attack
 Suffix
of Crushing 62 Melee Weapon Hits have (40-49)% chance to ignore Enemy Physical Damage Reduction
  • physical_damage
  • damage
  • physical
  • attack
 Suffix
of Overwhelming 80 Melee Weapon Hits have (50-60)% chance to ignore Enemy Physical Damage Reduction
  • physical_damage
  • damage
  • physical
  • attack
 Suffix
of the Hare 1 (6-9)% chance to gain Onslaught for 10 seconds on Killing Blow
  • attack
  • speed
 Suffix
of the Rabbit 1 (10-15)% chance to gain Onslaught for 10 seconds on Killing Blow
  • attack
  • speed
 Suffix
of the Fox 60 (16-25)% chance to gain Onslaught for 10 seconds on Killing Blow
  • attack
  • speed
 Suffix
of the Tundra 45 Killing Blows have (26-35)% chance to Shatter Enemies as though Frozen
  • attack
 Suffix
of the Snow Forest 45 Killing Blows have (36-45)% chance to Shatter Enemies as though Frozen
  • attack
 Suffix
of the Alpine Wood 72 Killing Blows have (46-60)% chance to Shatter Enemies as though Frozen
  • attack
 Suffix
of the Lamprey 70 (8-12)% of Leech is Instant against Low Life Enemies
  • attack
 Suffix
of the Leech 70 (13-16)% of Leech is Instant against Low Life Enemies
  • attack
 Suffix
of the Bloodsucker 81 (17-25)% of Leech is Instant against Low Life Enemies
  • attack
 Suffix
of Pursuit 70 Killing Blows against Rare Monsters have a (9-12)% chance
to grant one of their Modifiers for 60 seconds
  • attack
 Suffix
of the Chase 70 Killing Blows against Rare Monsters have a (13-18)% chance
to grant one of their Modifiers for 60 seconds
  • attack
 Suffix
of the Hunt 81 Killing Blows against Rare Monsters have a (20-30)% chance
to grant one of their Modifiers for 60 seconds
  • attack
 Suffix
of Desperation 81 Your hits can't be Evaded while you are on Low Life
Suffix
of Kindling 70 Killing Blows have a (8-12)% chance for Enemies to Explode, dealing a tenth of their maximum Life as Fire Damage
  • elemental
  • fire
  • attack
 Suffix
of Firewood 70 Killing Blows have a (13-16)% chance for Enemies to Explode, dealing a tenth of their maximum Life as Fire Damage
  • elemental
  • fire
  • attack
 Suffix
of Tinder 81 Killing Blows have a (17-25)% chance for Enemies to Explode, dealing a tenth of their maximum Life as Fire Damage
  • elemental
  • fire
  • attack
 Suffix
of Catalysing 1 Melee Weapon Damage Penetrates (5-7)% Elemental Resistances
  • elemental_damage
  • damage
  • elemental
  • attack
 Suffix
of Infusing 32 Melee Weapon Damage Penetrates (8-10)% Elemental Resistances
  • elemental_damage
  • damage
  • elemental
  • attack
 Suffix
of Empowering 60 Melee Weapon Damage Penetrates (11-13)% Elemental Resistances
  • elemental_damage
  • damage
  • elemental
  • attack
 Suffix
of the Unleashed 73 Melee Weapon Damage Penetrates (14-16)% Elemental Resistances
  • elemental_damage
  • damage
  • elemental
  • attack
 Suffix
of Overpowering 85 Melee Weapon Damage Penetrates (17-19)% Elemental Resistances
  • elemental_damage
  • damage
  • elemental
  • attack
 Suffix
of Execution 1 (40-47)% increased Melee Weapon Damage against Enemies that are on Low Life
  • damage
  • attack
 Suffix
of Elimination 28 (48-55)% increased Melee Weapon Damage against Enemies that are on Low Life
  • damage
  • attack
 Suffix
of Termination 47 (56-63)% increased Melee Weapon Damage against Enemies that are on Low Life
  • damage
  • attack
 Suffix
of Extermination 65 (64-71)% increased Melee Weapon Damage against Enemies that are on Low Life
  • damage
  • attack
 Suffix
of Assassination 80 (72-79)% increased Melee Weapon Damage against Enemies that are on Low Life
  • damage
  • attack
 Suffix
of Cleaving 1 (9-13)% increased Area of Effect if you've Killed Recently
Suffix
of Slaughter 1 (14-18)% increased Area of Effect if you've Killed Recently
Suffix
of Massacre 60 (19-25)% increased Area of Effect if you've Killed Recently
Suffix
of Skill 1 (15-19)% increased Melee Weapon Attack Speed
  • attack
  • speed
 Suffix
of Ease 65 (20-24)% increased Melee Weapon Attack Speed
  • attack
  • speed
 Suffix
of Mastery 85 (25-29)% increased Melee Weapon Attack Speed
  • attack
  • speed
 Suffix
of Acrimony 1 +(9-13)% to Damage over Time Multiplier with Melee Weapon Attacks
  • damage
  • attack
 Suffix
of Dispersion 34 +(14-18)% to Damage over Time Multiplier with Melee Weapon Attacks
  • damage
  • attack
 Suffix
of Liquefaction 58 +(19-23)% to Damage over Time Multiplier with Melee Weapon Attacks
  • damage
  • attack
 Suffix
of Melting 70 +(24-28)% to Damage over Time Multiplier with Melee Weapon Attacks
  • damage
  • attack
 Suffix
of Dissolution 84 +(29-33)% to Damage over Time Multiplier with Melee Weapon Attacks
  • damage
  • attack
 Suffix
of Rain 81 Weapon Attacks fire an additional Projectile if you've been Hit Recently
Suffix
of Hail 83 Weapon Attacks fire 2 additional Projectiles if you've been Hit Recently
Suffix
of Recycling 1 Gain (10-20) Mana per Enemy Killed
Suffix
of Draining 1 Gain (21-30) Mana per Enemy Killed
Suffix
of Absorption 38 Gain (2-3) Mana per Enemy Killed with Melee Weapons
Suffix
of Osmosis 50 Gain (4-5) Mana per Enemy Killed with Melee Weapons
Suffix
of Siphoning 60 Gain (31-40) Mana per Enemy Killed
Suffix
of Consumption 68 Gain (6-8) Mana per Enemy Killed with Melee Weapons
Suffix
of Assimilation 82 Gain (9-11) Mana per Enemy Killed with Melee Weapons
Suffix
of Rage 45 +(50-80)% to Critical Strike Multiplier against Enemies that are on Full Life
  • attack
  • critical
 Suffix
of Fury 45 +(81-105)% to Critical Strike Multiplier against Enemies that are on Full Life
  • attack
  • critical
 Suffix
of Ferocity 72 +(106-140)% to Critical Strike Multiplier against Enemies that are on Full Life
  • attack
  • critical
 Suffix
of the Wild 1 (25-35)% increased Duration of Elemental Ailments from Melee Weapon Attacks
  • elemental
  • attack
  • ailment
 Suffix
of the Untamed 42 (36-45)% increased Duration of Elemental Ailments from Melee Weapon Attacks
  • elemental
  • attack
  • ailment
 Suffix
of the Savage 60 (46-55)% increased Duration of Elemental Ailments from Melee Weapon Attacks
  • elemental
  • attack
  • ailment
 Suffix
of the Beast 82 (56-65)% increased Duration of Elemental Ailments from Melee Weapon Attacks
  • elemental
  • attack
  • ailment
 Suffix
of Charge 1 (31-40)% increased Mana Regeneration Rate if you have Shocked an Enemy Recently
Suffix
of Voltage 1 (41-50)% increased Mana Regeneration Rate if you have Shocked an Enemy Recently
Suffix
of Dynamism 60 (51-70)% increased Mana Regeneration Rate if you have Shocked an Enemy Recently
Suffix
of Enveloping 45 Gain 1 Mana per Enemy Hit with Melee Weapons
  • resource
  • mana
  • attack
 Suffix
of Siphoning 68 Gain 2 Mana per Enemy Hit with Melee Weapons
  • resource
  • mana
  • attack
 Suffix
of Devouring 84 Gain 3 Mana per Enemy Hit with Melee Weapons
  • resource
  • mana
  • attack
 Suffix
of Riposting 45 (9-13)% increased Attack Speed if you have Blocked Recently
Suffix
of Momentum 45 (14-18)% increased Attack Speed if you have Blocked Recently
Suffix
of Retribution 72 (19-25)% increased Attack Speed if you have Blocked Recently
Suffix
of Staggering 45 +(6-9)% Chance to Block Attack Damage if you've Stunned an Enemy Recently
Suffix
of Slamming 45 +(10-12)% Chance to Block Attack Damage if you've Stunned an Enemy Recently
Suffix
of Pummelling 72 +(13-15)% Chance to Block Attack Damage if you've Stunned an Enemy Recently
Suffix
of Restocking 1 (10-20)% increased Flask Charges gained from Kills
Suffix
of Replenishing 1 (21-30)% increased Flask Charges gained from Kills
Suffix
of Restocking 1 (11-15)% increased Flask Charges gained from Kills with Melee Weapons
Suffix
of Replenishing 40 (16-20)% increased Flask Charges gained from Kills with Melee Weapons
Suffix
of Pouring 60 (31-40)% increased Flask Charges gained from Kills
Suffix
of Pouring 72 (21-25)% increased Flask Charges gained from Kills with Melee Weapons
Suffix
of Overflowing 85 (26-30)% increased Flask Charges gained from Kills with Melee Weapons
Suffix
of Cannibalism 1 (9-13)% of Overkill Damage is Leeched as Life
Suffix
of Sacrifice 1 (14-18)% of Overkill Damage is Leeched as Life
Suffix
of Gorging 60 (19-25)% of Overkill Damage is Leeched as Life
Suffix
of Success 1 Gain (11-15) Life per Enemy Killed with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Victory 35 Gain (16-20) Life per Enemy Killed with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Triumph 62 Gain (21-25) Life per Enemy Killed with Melee Weapons
  • resource
  • life
  • attack
 Suffix
of Conquest 80 Gain (26-30) Life per Enemy Killed with Melee Weapons
  • resource
  • life
  • attack
 Suffix

AI Guides

In the ruthless and ever-challenging world of Wraeclast, Path of Exile (PoE) players continuously seek new ways to maximize their offensive capabilities. The Potent Poisonberry Tincture of Ire stands out as a formidable choice for those who specialize in poison and critical strikes with melee weapons. This article delves into the mechanics, benefits, and strategic uses of the Potent Poisonberry Tincture of Ire, providing insights on how to harness its power effectively.

Potent Poisonberry Tincture of Ire: Overview and Activation

The Potent Poisonberry Tincture of Ire is designed for players who excel in dealing poison damage and seek to enhance their critical strike multiplier. Here’s a detailed look at its features:

  • Inflicts Mana Burn Every 0.43 Seconds: When activated, the tincture causes Mana Burn, draining 1% of your maximum mana per stack per second.
  • 27% Chance to Poison with Melee Weapons: This tincture increases the chance to inflict poison with melee attacks, making it a valuable asset for poison-focused builds.
  • 94% Increased Damage with Poison from Melee Weapons: This significant boost in poison damage enhances your overall damage output, making your poison effects more lethal.
  • 35% Increased Effect: This further amplifies the potency of your poison and other effects, ensuring maximum damage over time.
  • 64% Increased Mana Burn Rate: The increased rate of Mana Burn necessitates careful mana management but allows for powerful, sustained offensive capabilities.
  • +24% to Melee Weapon Critical Strike Multiplier: This bonus significantly enhances the damage of your critical hits, making each strike more devastating.
  • Cooldown and Deactivation: The tincture can be deactivated manually or will automatically deactivate when your mana reaches zero, with a 6-second cooldown period following deactivation.
  • Level Requirement: Usable from level 45, making it accessible in mid-to-late game content.
  • Exclusive Activation: Only one tincture can be active in your belt at a time, necessitating careful selection based on your build and the situation.

Strategic Uses and Benefits

The Potent Poisonberry Tincture of Ire offers substantial boosts to poison damage and critical strikes, but its Mana Burn mechanic requires strategic management. Here are some key considerations:

  1. Enhancing Poison Builds:

    • Poison Focus: Builds that prioritize poison damage will benefit immensely from the tincture’s 27% chance to poison and 94% increased poison damage. Skills such as Viper Strike, Venom Gyre, or Pestilent Strike can see significant improvements in damage output.
    • Gear and Passives: Invest in gear and passive skills that further increase poison chance, duration, and damage to complement the tincture’s effects.

  2. Managing Mana Burn:

    • Mana Management: The tincture’s Mana Burn effect necessitates careful mana management. Ensure you have adequate mana regeneration or leech to sustain your attacks while using the tincture.
    • Cooldown Awareness: Be mindful of the 6-second cooldown period after deactivation. Plan your activation times around critical moments in combat to maximize effectiveness without leaving yourself vulnerable.

  3. Boosting Critical Strike Damage:

    • Critical Strike Multiplier: The +24% to melee weapon critical strike multiplier significantly enhances the damage of your critical hits, making each strike more devastating.
    • Synergistic Skills: Skills that benefit from high critical strike chance, such as Dual Strike or Lacerate, can take full advantage of the tincture’s boost, improving both burst and sustained damage output.

  4. Situational Activation:

    • Burst Damage Opportunities: Activate the tincture during key moments when burst damage is needed, such as against bosses or elite packs. The combination of increased poison chance, damage, and critical strike multiplier can turn the tide of battle.
    • Deactivation Strategy: Monitor your mana pool and manually deactivate the tincture before you run out of mana to avoid the cooldown period at inopportune times.

  5. Defensive Considerations:

    • Mitigating Mana Burn Risks: Use defensive skills and gear that offer mana recovery on hit or damage taken as mana to mitigate the risks of Mana Burn. This will help maintain your mana pool and prolong the active period of the tincture.

Conclusion

The Potent Poisonberry Tincture of Ire is a powerful tool in the arsenal of any Path of Exile player focusing on poison damage and critical strikes. By providing significant increases in poison chance, damage, and critical strike multiplier, it enhances both precision and combat efficiency. However, its Mana Burn mechanic requires careful management to maximize its benefits. Properly utilized, the Potent Poisonberry Tincture of Ire can significantly boost your combat effectiveness, allowing you to unleash devastating poison attacks with lethal precision. Embrace the power of the tincture, master its mechanics, and let your venomous fury dominate in the perilous world of Wraeclast.

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